Dual-Dual Throats on any Dual Port head will perform much better than any combination..
Properly tuned(which includes jetting) will yield awesome performance and great gas milage.
really no matter the motor size .. ther are many other factors that could contribute to poor MPG.. but if everything is done correctly you can have the best of both worlds no problems..
if your running single port heads.. then Kadrons seem to be a great choice.. I have never personally owned a set ... but from what I see they are great for performance and driveability.
remember a fully tuned everywhere else motor/car can run awesome.. so make sure everything is set and working properly.. things like compression loss -valve seating-poor oil delivery- iginition-exhuast - transmission issues- tire pressure..all sorts of other items contirbute to power consumption and loss or gain.. don't forget them and think throwing on carbs answers performance needs..
my.02